Collaboration Details

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Title of Collaborative Activity:

Drug Induced Liver Injury Network (DILIN)

Description of Collaborative Activity:

Both a prospective and retrospective database containing cases of drug-induced liver disease, Drug Induced Liver Injury Network (DILIN) is funded by a cooperative agreement and includes eight clinical centers and a central data coordinating center. One of the goals of DILIN is to establish a database of well-characterized cases of drug-induced liver injury along with serum, DNA, and tissue samples that will facilitate research on the mechanisms of hepatic injury due to drugs. Cases of liver injury due to herbal medications are also included. DILIN will develop standardized definitions of drug-induced liver disease and standardization of scoring systems for causality. Three employees of FDA serve as ad hoc members on the committee overseeing the network activities.

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