Collaboration Details

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Title of Collaborative Activity:

Evaluate the Efficacy of an Antiviral Drug

Description of Collaborative Activity:

The purpose of this Intra-agency Agreement (IAA) is to establish a formal working relationship between CDC and NICHD as co-sponsors of a multicenter clinical study to evaluate the efficacy of an antiviral drug, tenofovir, for prevention of hepatitis B virus (HBV) mother-to-child transmission from HBV-infected mothers with high HBV viral load. The study evaluates the critical issue of prevention of mother-to-child transmission (MTCT) of HBV in the high risk situation of elevated maternal HBV virus load [HBV e antigen positive (HBeAf+] mothers). Infants infected at birth with HBV are at high risk of both cirrhosis and liver cancer during adulthood.

Type of Collaborative Activity:

Research Initiative

Year the Collaborative Activity Originated:


NIH Participating Institutes/Centers/Office of the Director:


HHS Agency Collaborators on this Activity: