Description of Collaborative Activity: |
Test compounds against isolates of C. gattii and C. neoformans. The panel of isolates consists of 300 genotyped isolates of C. gattii from all over the world and 100 isolates of C. neoformans which originated in South Africa. Each isolate would be tested once following the broth microdilution protocol as outlined in the Clinical and Laboratory Standards (CL5I) document M27-A3 (Clincal Laboratory Standards Institute, 2008). All isolates tested would already have fluconazole Minimum Inhibitor Concentration (MIC) data available for comparison. |