Description of Collaborative Activity: |
Collaboration with M Choi, WC Cheng and A Badano from the Imaging Physics Lab, Divison of Imaging and Applied Mathematics Office of Science and Engineering Labs, CDRH, FDA. The project consists of developing software and establish validations for the automated determination of marrow cellularity and enumeration of plasma cells identified by immunohistochemistry (IHC) using a CD138 antibody. This initial effort should serve as proof of principle for a broader plan to utilize IHC-based automated quantitation of different types of cells in bone marrow core biopsies for diagnosis, prognosis and therapy monitoring of marrow disorders. |