Description of Collaborative Activity: |
The Clinical Pharmacology Quality Assurance program provides proficiency test materials for the DAIDS clinical pharmacology labs, both domestic and internationally. The Proficiency testing panels include replicate samples of antiretroviral drugs of unknown concentration, which are determined by the labs using liquid-chromatography mass spectrometry (LC-MS/MS) methodology. Labs must determine concentrations with high accuracy and precision to 'Pass" the panel. In a partnership with the Center for Disease Control, two of their labs have been included to participate in the CPQA proficiency Testing Program. They ae the International Laboratory Branch Bioanalytical Laboratory and the Analytical and Clinical Evaluations Laboratory of the domestic CDC HIV Prevention Program. The CPQA also did validations of their drug quantification assay protocols and have conducted site visits to evaluate their operations. The CPQA contract operates through TRP in DAIDS. |
