Description of Collaborative Activity: |
The NCATS OpenData COVID-19 portal is a resource designed to rapidly and openly share SARS-CoV-2 screening data and assay information with the global health community. NCATS scientists have worked to develop a number of SARS-CoV-2-related assays (18 high-throughput screens to date) to measure over 10,000 compounds, including the NCATS Pharmaceutical Collection of nearly 3,000 approved drugs, for their activity against the virus. These data include all positive and negative results from a diverse panel of repurposing screens, and can be viewed, sorted, searched and exported directly from the portal website. Screening datasets were uploaded to the website as soon as they were validated and available. This resource aims to reimagine the early translation process by sharing screening data immediately and without restrictions. We hope to enable a variety of drug repurposing activities and allow researchers to formulate and test hypotheses, prioritize research opportunities and speed the search for effective therapies against the virus and the disease it causes. In collaboration with ACTIV TRACE, the OpenData Portal has evolved to share a wider array of data, including the most comprehensive public database of in vitro therapeutic activity data available against known variants. To date, this living resource has compiled more than 17,000 activity data points from tested variants, curated from nearly 440 different publications/datasets. |
