Research Initiative

Collaboration Title	Collaboration Type	HHS Participating Agencies	NIH Participating Institutes/ Centers/ Office of the Director	Year Collaboration Originated
A nested case-control study of circulating per- and polyfluoroalkyl substances (PFAS) and renal cell carcinoma	Research Initiative	CDC	NCI	2018
A nested case-control study of circulating per- and polyfluoroalkyl substances (PFAS) and uterine and ovarian cancers	Research Initiative	CDC	NCI	2019
A Study of Markers of Cosmic Radiation Exposure and Effect Among Flight Crews	Research Initiative	CDC	NCI	1998
A5349/TBTC S31 - Rifapentine - Containing Treatment Shortening Regimens for Pulmonary Tuberculosis: A Randomized, Open-Label, Controlled Phase 3 Clinical Trial	Research Initiative	CDC	NIAID	2015
Abuse Liability Evaluation for Research, Treatment, and Training (ALERTT)	Research Initiative	FDA	NIDA	2011
Accelerating Medicines Partnership Schizophrenia (AMP SCZ)	Research Initiative	FDA		2020
Action for Health in Diabetes Extension (Look AHEAD-E)	Research Initiative	CDC, IHS	NIA, NIDDK	1999
Acute Flaccid Myelitis (AFM) Studies	Research Initiative	CDC	NIAID, NICHD, NINDS	2018
Adolescent Brain Cognitive Development (ABCD) Study	Research Initiative	CDC	NCI, NIAAA, NICHD, NIDA, NIMH, NIMHD, NINDS, OD/ DPCPSI/ OBSSR	2016
Advancing American Kidney Health Initiative	Research Initiative	CDC, CMS, FDA, ASPE, ASPR, HRSA, HIS, OCR	NIDDK, NIEHS	2019
AMP Bespoke Gene Therapy Program/Bespoke Gene Therapy Consortium (BGTC)	Research Initiative	FDA	NCATS, NHLBI, NIMH, NINDS	2019
Analgesic Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION)	Research Initiative	FDA	NCATS, NCI, NIAAA, NIDA, NINDS	2011
Assessment of Inhalation Exposures to Indoor and Occupational Aerosols	Research Initiative	CDC	NIEHS	2014
Assisted Outpatient Treatment for Individuals with Serious Mental Illness	Research Initiative	HRSA, SAMHSA, ASPE	NIMH	2016
Biomarkers of Exposure and Effect in Agriculture (BEEA)	Research Initiative	CDC	NCI	2018
Botanical Safety Consortium	Research Initiative	FDA	NCCIH, NEIHS	2019
Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative	Research Initiative	FDA	NCCIH, NEI, NIA, NIAAA, NIBIB, NICHD, NIDA, NIDCD, NIMH, NINDS, OD/ DPCPSI/ OBSSR	2014
Cancer Moonshot Award	Research Initiative	OS	NCI, NIDCD	2019
Circulating Estrogens, Androgens, and Progestogens and Risk of Breast Cancer in the PLCO Cohort	Research Initiative	CDC	NCI	2018
CLARITY - Mammary Gland efforts	Research Initiative	ATSDR	NIEHS	2016
Clinical Research Using Medicare Data from the Virtual Research Data Center (VRDC)	Research Initiative	CMS	NLM	2016
Collaborative Use Repurposing Engine ID (CURE ID)	Research Initiative	FDA	NCATS	2013
Community Engagement Alliance Against COVID-19 Disparities (CEAL) Initiative	Research Initiative	AoA	NICHD, OD/ DPCPSI/ ORWH	2020
Computational Toxicology for NIH Medications Discovery	Research Initiative	FDA	NIDA	2000
Computer-aided Diagnosis for Radiology Images	Research Initiative	FDA	CC	2004
CONSUMER PRODUCT CHEMICAL EXPOSURES IN PREGNANCY AND THEIR CUMULATIVE IMPACT ON DISORDERS OF FETAL GROWTH	Research Initiative	CDC	NIEHS	2020
Countermeasures Against Chemical Threats (CounterACT) Research Network	Research Initiative	CDC, FDA, OS	NEI, NIAID, NIAMS, NICHD, NIEHS, NIGMS, NINDS, NLM	2006
Country Work in Cancer Research and Cancer Control Planning Strengthening; Kenya	Research Initiative	CDC	FIC, NCI, NIAID	2013
Diabetes Prevention Program Outcomes Study (DPP/DPPOS)	Research Initiative	CDC	NCI, NHLBI, NIDDK, NIA	1994
Diabetic Retinopathy Clinical Research Network	Research Initiative	OS	NEI, NIDDK	2002
Diagnosis, Treatment, and Medical Service Utilization in Medicare and Medicaid Population	Research Initiative	CMS	CC	2011
Diet-induced Hypomethylation in Preneoplastic Liver/Genetics & Epigenetics of Susceptibility to Non-Alcoholic Fatty Liver Disease	Research Initiative	FDA	NCI	2004
Digital Quantitation of Plasma Cells in Marrow Biopsies	Research Initiative	FDA	CC	2011
Disaster Research Response Project (DR2)	Research Initiative	ATSDR, CDC, FDA, IOS	NIEHS, NLM, OD/ DPCPSI	2013
Early Intervention to Promote Cardiovascular Health of Mothers and Children (ENRICH) Multisite with Coordinating Center	Research Initiative	HRSA	NHLBI, NICHD, NIDDK, OD/ DPCPSI/ OBSSR, ODP	2019
Ebola Clinical Research Response in Democratic Republic of the Congo	Research Initiative	CDC	NIAID	2018
Ebola Clinical Research Response in West Africa (Guinea, Liberia)	Research Initiative	CDC, FDA	NIAID	2014
Environmental Phthalate Exposures in Pregnancy in Relation to Fetal and Placental Development	Research Initiative	CDC	NIEHS	2020
Exploratory/Developmental Grants Related to the World Trade Center Health Program (R21)	Research Initiative	CDC	NIA	2019
Extracellular Ribonucleic Acid (RNA) Communication	Research Initiative	FDA	NCATS, OD/ DPCPSI/ OSC	2013
Eye Research Collaboration	Research Initiative	FDA	NEI	2014
FDA Collaboration - Psilocybin Research	Research Initiative	FDA	CC	2020
Federal Interagency Forum for Child and Family Statistics	Research Initiative	ACF, AHRQ, CDC, HRSA, OS, SAMHSA	NICHD, NIMH	2010
Federal Interagency Task Force on the Arts and Human Development	Research Initiative	ACF, ACL, SAMHSA	NCCIH, NCI, NIA, NICHD, NIMH, OD/ DPCPSI/ OBSSR	2011
FNIH Advanced Medicines Partnership on Gene Therapy	Research Initiative	FDA	NCATS	2019
FNIH Biomarkers Consortium	Research Initiative	CMS, FDA	NCATS, NCI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NICHD, NIDA, NIDCR, NIDDK, NIEHS, NIMH, NINDS	2006
Genetic Studies in the National Birth Defects Prevention Study (NBDPS)	Research Initiative	CDC	NHGRI	2014
Global Environmental and Occupational Health (GEOHealth)	Research Initiative	CDC	FIC, NCI, NIEHS, OD/ DPCPSI/ ORWH	2011
Global Health - Household Air Pollution Investigation Network (HAPIN)	Research Initiative	CDC	FIC, NCI, NHLBI, NICHD, NIEHS, OD/ DPCPSI/ OSC	2016
Global Ingredient Archival System (GINAS)	Research Initiative	FDA	NCATS	2013
HCS Research Collaboratory	Research Initiative	AHRQ, CDC, CMS, FDA, OS	OD/ DPCPSI/ OSC, ODP	2012
Health and Retirement Study (HRS)	Research Initiative	CDC, CMS	NIA	1992
HealthMap: Knowledge Management for Emerging Infectious Disease Intelligence	Research Initiative	IOS	NLM	2009
Helicobacter pylori Genome Project (HpGP)	Research Initiative	CDC	NCI, NLM	2016
Hepatitis B Research Network	Research Initiative	CDC	NCI, NIDDK	2008
HHS Action Plan for the Prevention, Care, and Treatment of Viral Hepatitis Interagency Implementation Group (VHIG)	Research Initiative	AHRQ, CDC, CMS, FDA, HRSA, IHS, SAMHSA	NIAID, NIDA, NIDDK, NIMHD	2011
HIV Pre-exposure Prophylaxis (PrEP) Implementation Science in HRSA Primary Health Care Settings	Research Initiative	HRSA	NIMH	2020
HIV/AIDS Cancer Match Study (HACM)	Research Initiative	CDC	NCI
Hospice to Palliative Care: Maximizing Patient Preferences and Cost Savings	Research Initiative	AHRQ	CC	2010
HRSA Maternal and Child Health Bureau Grand Challenges: remote pregnancy monitoring panelist	Research Initiative	CDC, CMS, HRSA	NICHD
Human skin sensitization data set	Research Initiative	FDA	NIEHS	2020
Image-guided Interventional Therapeutics	Research Initiative	FDA	CC, NCI	2004
Implementation Research in HRSA Ryan White Sites: Screening and Treatment for Mental and Substance Use Disorders to Further the National “Ending the HIV Epidemic” (EHE) Goals	Research Initiative	HRSA	NIDA, NIMH	2020
Improving Genomics/Omics Technical Standards and Molecular Tools for Prebiotic Probiotic Research and Development Working Group	Research Initiative	CDC, FDA, OS	NCCIH, NCI, NHGRI, NIDA, NLM	2016
In Vitro Assessment of Dermal Hypersensitivity: Using Alternative Methods to Predict Skin Sensitization	Research Initiative	FDA	NIEHS	2018
Industrywide exposure assessment study of workers exposed to graphene and other two-dimensional nanomaterials	Research Initiative	CDC	NIEHS	2018
Interagency Workgroup on Technology to Facilitate Aging in Place	Research Initiative	ACL, CMS, FDA	NCI, NHLBI, NIA, NIBIB, NINDS, NINR	2014
Journal of Women's Health Special Issue on Maternal Morbidity and Mortality	Research Initiative	ACF, HRSA, IHS, OASH	NCATS, NCCIH, NHLBI, NIA, NIAID, NICHD, NIDDK, NIEHS, NINR, NIMH, NIMHD, ODP, NIBIB, OD/ DPCPSI, OD/ DPCPSI/ ORWH	2019
Kaposi Sarcoma and HHV8 in Sickle Cell and Other Ugandan Populations	Research Initiative	CDC	NCI	2004
Kidney Innovation Accelerator (KidneyX)	Research Initiative	CMS, FDA	NIDDK	2018
Leveraging Novel Technologies for Chronic Disease Management for Aging Underserved Populations	Research Initiative	OASH	NHLBI	2020
Machine learning methods for literature data extraction	Research Initiative	FDA	NIEHS	2018
Microphysiological Systems for Drug Efficacy and Toxicity Testing	Research Initiative	FDA	NCATS, NCI, NEI, NHLBI, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCR, NIDDK, NIEHS, NIGMS, NINDS, NINR, OD/ DPCPSI/ ORWH, OD/ DPCPSI/ OSC	2012
Models of Infectious Disease Agent Study (MIDAS)	Research Initiative	CDC	FIC, NIAID, NIGMS	2003
Multinational Influenza Seasonal Mortality Study (MISMS) Research	Research Initiative	FDA, OS	FIC, NHLBI, NIAID, NLM	2001
Nanotechnology Characterization Laboratory	Research Initiative	FDA	NCI, NIEHS	2004
National Collaborative on Childhood Obesity Research (NCCOR)	Research Initiative	CDC	NCI, NHLBI, NICHD, NIDDK, OD/ DPCPSI/ OBSSR, ODP	2010
National Emerging Contaminant Research Initiative	Research Initiative	CDC, ATSDR, FDA	NIEHS
National Neurological Conditions Surveillance System (NNCSS)	Research Initiative	CDC	NINDS	2016
National Robotics Initiative (NRI)	Research Initiative	CDC	NCATS, NEI, NIA, NIBIB, NINR	2009
Native American Research Center for Health (NARCH)	Research Initiative	IHS	CSR, NCI, NIA, NIAAA, NIAID, NIAMS, NICHD, NIDA, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, OD/ DPCPSI/ OBSSR, OD/ DPCPSI/ ORWH	2000
Natural Compounds to Reduce Nitrate in Meat Products: Phytome	Research Initiative	CDC	NCI	2016
Natural Experiments and Effectiveness Studies in the Prevention and Control of Diabetes	Research Initiative	CDC	NIDDK	2010
NCI Scientific Steering Committees (SSCs)	Research Initiative	FDA	NCI	2011
NCI/CCR-FDA Clinical Investigator Program	Research Initiative	FDA	NCI	2015
NCI/FDA Memorandum of Understanding for Proteomics	Research Initiative	FDA	NCI	2007
Networking and Information Technology Research and Development (NITRD)	Research Initiative	AHRQ	NIGMS	1991
NIA IMPACT Collaboratory Transforming Dementia Care	Research Initiative	CDC	NIA	2019
Non-animal approaches to assess cardiotoxicity hazard	Research Initiative	FDA	NIEHS	2018
Observational Cohort to Assess Therapeutic Efficacy and Emergence of HIV Drug Resistance following Initiation of Tenofovir-Lamivudine-Dolutegravir (TLD)	Research Initiative	CDC	NIAID	2018
Occupational Exposure Assessment of Emerging Per- and Polyfluoroalkyl Substances (PFAS)	Research Initiative	CDC	NIEHS	2020
Operation Warp Speed (OWS)	Research Initiative	CDC, FDA, ASPR	NIAID	2020
P63, P13K and RAS oncogenes in tumorigenesis, immune deregulation and therapy of squamous cell carcinoma	Research Initiative	FDA	NIDCD	2014
Pediatric Device Consortia Grants Program	Research Initiative	FDA	NICHD	2009
Polyhalogenated Aromatic Hydrocarbons (PHAH) and Thyroid Cancer	Research Initiative	CDC	NCI	2010
Preclinical Assessment of Phage Therapy for Pathogen Decolonization	Research Initiative	FDA	NIAID	2015
President's Emergency Plan for AIDS Relief (PEPFAR) Implementation Science/Combination Prevention	Research Initiative	CDC	FIC, NCI, NIAAA, NIAID, NIDA, NIMH, OD/ DPCPSI/ OAR	2005
Quantitative Data Mining for Drug-Adverse Event Safety Signal Detection Using MEDLINE	Research Initiative	FDA	NLM	2012
Racial/Ethnic Variation of HPV Type Distribution in High-Grade Cervical Precancers and Invasive Cancers in the United States	Research Initiative	CDC	NCI	2016
Rapid Acceleration of Diagnostics Tech Program (RADx Tech)	Research Initiative	CMS, FDA, CDC, ASPR	NIBIB	2020
Regenerative Medicine Project	Research Initiative	FDA	NIA	2017
Registry-based studies of hematologic malignancy incidence and survivorship	Research Initiative	FDA	NCI	2019
RePORT South Africa	Research Initiative	CDC, OS	NIAID	2016
Research in Diabetes Mellitus, Its Complications, and Obesity	Research Initiative	IHS	NIDDK	1965
Research to Guide Practice Enhancing HIV/AIDS Platforms to Address Non- Communicable Diseases in Low Resource Settings (HIV/NCD Integration Project)	Research Initiative	CDC	FIC, NCI, NHLBI, NIAID, NICHD, NIDDK, NIMH, NIMHD, NINDS, NINR, OD/ DPCPSI/ OAR	2014
Role of IFNL4 in immune response to infection	Research Initiative	FDA	NCI	2018
SEARCH for Diabetes in Youth	Research Initiative	CDC	NIDDK	2001
Somatic Cell Genome Editing	Research Initiative	FDA	NCATS, NCI, NHGRI, NHLBI, NIAID, NIAMS, NIDDK, NIMH, NINDS, OD/ DPCPSI/ ORIP, OD/ DPCPSI/ OSC	2017
Specificity and Quality of Influenza-Specific Antibodies	Research Initiative	FDA	NIAID	2015
Standards for Genetic Testing Report	Research Initiative	AHRQ, CDC, IOS	NHGRI, NLM	2007
Stimulating Peripheral Activity to Relieve Conditions	Research Initiative	FDA	NCATS, NCCIH, NCI, NEI, NHLBI, NIAID, NIBIB, NICHD, NIDA, NIDCD, NIDDK, NIMH, NINDS, OD/ DPCPSI/ OSC	2016
Supporting Early Psychosis Research and Implementation	Research Initiative	OS	NIMH	2018
The Effect of Various Drugs on the Retina	Research Initiative	FDA	NEI	2014
The Environmental Determinants of Diabetes in the Young (TEDDY)	Research Initiative	CDC	NIAID, NICHD, NIDDK, NIEHS	2002
The Epidemiology of Burkitt Lymphoma in East-African Children and Minors (EMBLEM)	Research Initiative	CDC, FDA	NCI, NHGRI, NHLBI	2010
The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)	Research Initiative	CDC	NIDDK	2016
The Golestan Cohort Study of Esophageal Cancer	Research Initiative	CDC	NCI	2018
The Impact of Tobacco Use on Oral Health and the Oral Microbiome	Research Initiative	CDC, FDA	NCI	2012
The Incidence of Breast and Other Cancers Among Female Flight Attendants	Research Initiative	CDC	NCI	1998
The NIH Helping to End Addiction Long Term (HEAL) Initiative	Research Initiative	AHRQ, CDC, CMS, HRSA, OS, SAMHSA	NCATS, NCCIH, NHLBI, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDDK, NIMH, NINDS, OD/ OSP	2018
Tissue Chip Testing Centers	Research Initiative	FDA	NCATS	2016
Tobacco Centers of Regulatory Science (TCORS)	Research Initiative	FDA	ODP	2013
Tobacco Product Disease Risks	Research Initiative	FDA	NCI	2016
Tobacco Regulatory Science Program (TRSP)	Research Initiative	FDA	CSR, NCI, NHLBI, NIAAA, NICHD, NIDA, NIEHS, OD/ OER, ODP	2012
Transplant Cancer Match Study	Research Initiative	HRSA	NCI	2005
Trial to Assess Chelation Therapy 2 (TACT2)	Research Initiative	CDC	NCCIH, NHLBI, NIDDK, NIEHS	2016
Tribal Epidemiology Centers Program	Research Initiative	IHS, CDC	NIMHD, OD/ DPCPSI/ THRO	2002
Urine biomarkers and risk of lung cancer in the Sisters Study	Research Initiative	CDC, FDA	NCI	2019
Urine biomarkersof tobacco and opium and risk of cancers anad heart disease	Research Initiative	CDC, FDA	NCI	2020
Using Real-time Prescription and Insurance Claims Data to Support the HIV Care Continuum	Research Initiative	CDC	NIMH	2019
Validation study of the electrophilic allergen screening assay	Research Initiative	FDA	NIEHS	2017
Vision Research Collaborative	Research Initiative	FDA	NEI	2020

Funding levels reported in the Fiscal Year 2020 Intra-Agency Collaborations Reporting System (CRS) may not be consistent with funding levels reported under the Estimates of Funding for Various Research, Condition, and Disease Categories (RCDC) at the NIH Office of Budget Website at http://report.nih.gov/categorical_spending.aspx. The current process, implemented in 2008 through the Research, Condition, and Disease Categorization (RCDC) system, uses sophisticated text data mining (categorizing and clustering using words and multiword phrases) in conjunction with NIH-wide definitions used to match projects to categories. RCDC use of data mining improves consistency and eliminates the wide variability in defining the research categories reported. The definitions are a list of terms and concepts selected by NIH scientific experts to define a research category. The research category levels represent the NIH’s best estimates based on the category definitions.